Nevoid Basal Cell Carcinoma Syndrome (Basal Cell Nevus Syndrome) Differential Diagnoses

Updated: Jun 14, 2021
  • Author: Daniel Berg, MD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

The diagnosis of nevoid basal cell carcinoma syndrome (NBCCS) remains a clinical one, despite advances in genetic understanding of this disease.

Radiologic abnormalities, such as rib abnormalities, or asymptomatic findings, such as palmar pits, may be present at a higher frequency in childhood; these findings may be helpful in making an early diagnosis. [22]

Other problems to be considered in the diagnosis of NBCCS include the following:

  • Bazex syndrome (X-linked dominant syndrome with BCCs, follicular atrophoderma, hypertrichosis, and hypohidrosis of the face and the head)

  • Rombo syndrome

  • Unilateral nevoid BCC with comedones

Differential Diagnoses