Extramammary Paget Disease Medication

Updated: Jul 21, 2021
  • Author: Richard Harold "Hal" Flowers, IV, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

Topical imiquimod and fluorouracil are considered as possible treatment options when surgery is a challenge or contraindicated. However, more studies are needed to confirm the efficacy of topical therapies for patients with extramammary Paget disease (EMPD).



Class Summary

These agents modulate key factors of the immune system.

Imiquimod (Aldara, Zyclara)

Imiquimod is an immune response modifier that induces apoptosis by binding to Toll-like receptors seven and eight on monocytes, macrophages, and dendritic cells. It is indicated to treat clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp.


Antineoplastics, Antimetabolite

Class Summary

These agents inhibit cell growth and proliferation.

Fluorouracil (Carac, Efudex, Fluoroplex)

Fluorouracil is used topically. It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid via inhibition of thymidylate synthetase and, subsequently, cell proliferation.