Dermatologic Manifestations of Gardner Syndrome Treatment & Management

Updated: Apr 05, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Medical Care

Treatment of the cutaneous manifestations of Gardner syndrome depends on the symptomatic or cosmetic nature and the location of the cysts. Treatment is similar to that used for ordinary cysts and involves excision [29] or use of intralesional steroids if the cysts are inflamed. Conservative management with chemotherapy or tyrosine kinase inhibitors is now being favored. [30]

Antiestrogens and anthracycline-containing regimens may have a favorable radiological response rate against desmoid tumors and may be a viable option in some patients. [31]

Most parents believed it was their responsibility to inform young family members about genetic testing results, an often emotionally challenging matter encouraging preventive screening and possible lifestyle adaptions. [25]


Surgical Care

Colectomy [32] is recommended for Gardner syndrome patients if 30 or more polyps are detected on colonoscopy or if biopsy results reveal dysplasia or malignant degeneration. Preserving the rectum results in a 25-59% chance of rectal carcinoma occurring in Gardner syndrome patients; therefore, rectal mucosal resection is recommended. Total gastroduodenectomy with pancreatic preservation may be desirable in some settings. [33]

Generally, cutaneous findings do not require treatment. Osteomas may require excision if they are severely deforming or if they interfere with function.

Also see the General Surgery article Gardner Syndrome.