Acrokeratosis Paraneoplastica Treatment & Management

Updated: Nov 05, 2021
  • Author: Katherine R Garrity, MD; Chief Editor: William D James, MD  more...
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Medical Care

Treatment of acrokeratosis paraneoplastica depends on the type and stage of the underlying neoplasm. Successful treatment of the underlying malignancy typically improves the acrokeratosis paraneoplastica skin lesions.

Recurrence of acrokeratosis paraneoplastica skin lesions in a successfully treated patient implies a recurrence of the malignancy. [24, 25]

If the malignancy is untreatable or does not respond to treatment, acrokeratosis paraneoplastica skin-directed therapy may improve the eruption; however, the response to treatment is variable and often unsatisfactory. [12]

Improvement has been reported with the use of topical and systemic retinoids, topical and oral corticosteroids, salicylic acid, topical vitamin D analogues, and psoralen plus UVA (PUVA). [13]

One report suggests a role for zinc supplementation in patients with acrokeratosis paraneoplastica. [2]



Consultation with an internal medicine specialist for a malignancy workup is appropriate with an acrokeratosis paraneoplastica diagnosis.

Consultation with a hematologist, oncologist, otolaryngologist, pulmonologist, and/or gastroenterologist also can assist with focused evaluations related to acrokeratosis paraneoplastica.