Lobomycosis Treatment & Management

Updated: Apr 14, 2017
  • Author: Manuel Valdebran, MD; Chief Editor: Dirk M Elston, MD  more...
  • Print

Medical Care

To date, there have not been any investigations using pharmacological regimens; however, reports have described efficacy for certain regimens in nonsurgical candidates.

A case report described a therapeutic response to 1-year treatment with a combination of clofazimine at 100 mg/d and itraconazole at 100 mg/d. [75] Clofazimine alone improved the lesions in a few patients. Another case report described a patient in Peru who was cured after 27 months of posaconazole with no recurrence after 5 years of follow-up. [76]

Combination itraconazole and clofazimine has been used in the treatment of lobomycosis on the face, with no relapse after 3-year follow up. [77]

Patients with lobomycosis and concurrent leprosy respond to multibacillary therapy, with reduction of pruritus and the size of mycotic nodules. [78]


Surgical Care

The treatment of choice for patients with a localized, surgically amenable form of the disease is surgical excision. [79, 80] Recurrence at the excision site is not uncommon; however, if the disease is detected early, surgical excision may be curative. [72, 79] The major indication for excision is the prevention or correction of disfigurement.

In order to prevent recurrence, itraconazole with cryosurgery has been used successfully to treat relapsing cases. [81]



No specific dietary changes are required.