Mondor Disease Workup

Updated: Apr 07, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

No laboratory studies are necessary for diagnosis. With Mondor disease of the penis, an uncommon condition usually involving the superficial dorsal veins, ultrasound and Doppler ultrasonography examination is not useful for diagnosis but may help the clinician show the patient that the disease is a benign condition. [34]

Immunohistochemical staining for CD31 and D240 is a good method to distinguish small veins from lymphatic vessels, making it a valuable technique for diagnosing Mondor disease. [9]


Imaging Studies

Mammography results are always negative. This finding helps to differentiate Mondor disease from lesions, such as cancer, cysts, and fibroadenomata, which have positive radiography shadows. [35]

Ultrasonography may show Mondor disease to good advantage [36]


Histologic Findings

From histologic studies, 4 phases of the disease have been delineated: thrombus formation; thrombus organization; recanalization; and residual, thick-walled fibrosis. [37]