Lymphangioma Differential Diagnoses

Updated: Apr 05, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Lymphangioma circumscriptum may resemble warts, metastatic carcinoma of the skin, lymphangiectasis, herpes simplex, and herpes zoster. [1]  Metastasis of a papillary thyroid microcarcinoma may appear as a cystic lymphangioma of the neck. [17]

Other cysts and soft subcutaneous masses should be considered.

Occasionally, acquired lymphangioma circumscriptum of the vulva may mimic genital warts, appearing as verrucous plaques, [18, 19, 20, 21] although these common viral infections may occur with the lymphangiomas and display overlapping clinical features. [22] Resulting from interference in the lymph drainage, acquired lymphangioma circumscriptum is often related linked to oncological surgical procedures.

Genital lymphangiomas may be complicated by cellulitis. [9]

Cystic hygroma can be associated with the following congenital disorders:

Patients with cystic hygroma should undergo cytogenetic analysis for chromosomal aneuploidy. Parents should receive genetic counseling because aneuploidic conditions can recur in subsequent pregnancies. [24]

Differential Diagnoses