Peripheral Giant Cell Granuloma Clinical Presentation

Updated: Jun 19, 2018
  • Author: Carl M Allen, DDS, MSD; Chief Editor: Jeff Burgess, DDS, MSD  more...
  • Print


Peripheral giant cell granuloma has a relatively rapid growth rate, often attaining a size of 1 cm within a few months. Lesions are generally asymptomatic. See image below.

This asymptomatic bluish-purple nodule developed o This asymptomatic bluish-purple nodule developed on the edentulous mandibular alveolar ridge of a 76-year-old man.

Physical Examination

Clinical examination shows a dusky purple, sessile or pedunculated, smooth-surfaced, dome-shaped papule or nodule. Most lesions are less than 1.5 cm in diameter, though infrequently, a peripheral giant cell granuloma may grow as large as 5 cm in greatest dimension. [7]

The lesion is always located on the alveolar mucosa or the gingiva, and 70% are found in the anterior segments of the jaws, such as in the premolar, canine, and incisor regions. A slight predilection for the mandible is observed in most reported series. Surface ulceration is often present.

See the image below.

A 10-year-old boy developed this painless purple p A 10-year-old boy developed this painless purple papule of the maxillary facial alveolar process over a 3-month period. Biopsy helped confirm the diagnosis of peripheral giant cell granuloma.