Eosinophilic Ulcer Differential Diagnoses

Updated: Apr 10, 2017
  • Author: Marc Zachary Handler, MD; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Diagnostic Considerations

Also consider noma (necrotizing stomatitis), Epstein-Barr virus infection, and atypical herpes stomatitis (in patients who are immunocompromised).

Occasionally, lesions may demonstrate atypical histologic features. These lesions have been misdiagnosed as non-Hodgkin lymphoma and squamous cell carcinoma, and unnecessary radical treatment may result. Conversely, CD30-positive anaplastic lymphomas have been misdiagnosed as eosinophilic ulcers; therefore, immunohistochemical studies may be needed to confirm the diagnosis. [13]

Differential Diagnoses