Oral Submucous Fibrosis Differential Diagnoses

Updated: Jun 18, 2018
  • Author: Nektarios I Lountzis, MD; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Amyloidosis: Hyalinized stroma can be distinguished from amyloid infiltration by using Congo red and thioflavine T staining under polarized and immunofluorescent light, respectively.
  • Generalized fibromatosis: Although soft tissue masses are not produced in the usual sense, the fibrosis of oral submucous fibrosis may be confused with generalized fibromatosis.
  • Oral manifestations of scleroderma: Scleroderma can be distinguished by other cutaneous, systemic, and characteristic laboratory findings. A case of localized plaque-type morphea was seen in a patient with long-standing oral submucous fibrosis. [53]
  • Oral lichen planus: Wickham striae can mimic atrophy and fibrosis.
  • Anemia: Pale oral mucosa can mimic atrophy and fibrosis.