Nicotine Stomatitis Medication

Updated: Aug 10, 2018
  • Author: James E Cade, DDS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Medication

Medication Summary

Medical therapy for nicotinic stomatitis is directed at smoking cessation. [20, 21]  Varenicline decreases the stimulatory effect from consuming nicotine products by blocking nicotine receptors. [22, 23]

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Nicotine substitutes

Class Summary

Nicotine substitutes are available as a transdermal patch, gum, an inhaler, or nasal spray.

Nicotine transdermal system (Nicotrol, NicoDerm CQ, Habitrol)

The nicotine transdermal system works best when used in conjunction with a support program (eg, counseling, group therapy, behavioral therapy).

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Antidepressant agents

Class Summary

These are used in conjunction with a support group and/or behavioral counseling.

Bupropion (Zyban)

Bupropion inhibits neuronal dopamine reuptake in addition to being a weak blocker of serotonin and norepinephrine reuptake.

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Nicotinic acetylcholine receptor partial agonists

Class Summary

Nicotinic acetylcholine receptor partial agonists bind to nicotine receptors and elicit mild nicotine central effects to ease withdrawal symptoms.

Varenicline (Chantix)

Varenicline is a partial agonist selective for alpha4, beta2 nicotinic acetylcholine receptors. Its action is thought to result from activity at a nicotinic receptor subtype, where its binding produces agonist activity while simultaneously preventing nicotine binding. Agonistic activity is significantly lower than nicotine. It also elicits moderate affinity for 5-HT3 receptors. Maximum plasma concentrations occur within 3-4 hours after oral administration. Following regular dosing, a steady state reached within 4 days.

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