Pseudoxanthoma Elasticum Medication

Updated: Jun 20, 2022
  • Author: Sheila Z Jalalat, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

The goals of pharmacotherapy for pseudoxanthoma elasticum (PXE) are to reduce morbidity and to prevent complications, although lifestyle modification remains the mainstay of treatment.

In a randomized, placebo-controlled trial of sevelamer hydrochloride, a phosphate binder, for the treatment of PXE, calcification and clinical severity scores improved but were not superior to placebo. The presence of magnesium in the placebo may have clouded the results by causing a therapeutic benefit. [56]


Hemorheologic agents

Class Summary

These agents are used for the symptomatic treatment of peripheral vascular disease.

Pentoxifylline (Trental)

Pentoxifylline alters erythrocyte rheology, which, in turn, reduces blood viscosity. It may be used but with extreme caution of hemorrhage.