Trichorrhexis Nodosa Differential Diagnoses

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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DDx

Diagnostic Considerations

Also consider the following:

Patients with syndromic diarrhea, also known as phenotypic diarrhea or tricho-hepato-enteric syndrome, have a congenital enteropathy with a distinct hair abnormality characterized by woolly hair that is easily removed and poorly pigmented. Hair-shaft microscopic analysis may show twisted hair (pili torti), anisotrichosis and poilkilotrichosis, trichorrhexis nodosa and longitudinal breaks, and trichothiodystrophy. [28]

A feature of normal healthy black African hair is an apparent increased fragility, with certain similarities to that reported for trichorrhexis nodosa (weathering secondary to physical damage). [29] This excessive structural damage is probably due to physical trauma (resulting from grooming) rather than an inherent weakness due to any structural abnormality.

Differential Diagnoses