Chromhidrosis Medication

Updated: May 14, 2018
  • Author: June Kim, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

The goals of pharmacotherapy for chromhidrosis are to reduce morbidity and to prevent complications.



Class Summary

Counterirritants may be used to treat chromhidrosis.

Capsaicin (Dolorac, Zostrix)

Capsaicin is derived from plants of the Solanaceae family. It may render the skin and joints insensitive to pain by depleting substance P in peripheral sensory neurons. Use 0.025% cream.


Neuromuscular blocking agents

Class Summary

These agents inhibit the transmission of nerve impulses at the neuromuscular junction of skeletal muscle and/or autonomic ganglia.

OnabotulinumtoxinA (BOTOX®)

OnabotulinumtoxinA prevents calcium-dependent release of acetylcholine and produces a state of denervation at the neuromuscular junction and postganglionic sympathetic cholinergic nerves in the sweat glands.