Perforating Folliculitis Medication

Updated: May 25, 2018
  • Author: Suguru Imaeda, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

The goals of pharmacotherapy are to eradicate the infection, reduce morbidity, and prevent complications. Studies have found that a combination of antistaphylococcal therapy and a topical corticosteroid lotion may help in controlling perforating folliculitis in patients with chronic renal failure.



Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Amoxicillin and clavulanate (Augmentin, Amoclan)

Amoxicillin and clavulanate treat bacteria resistant to beta-lactam antibiotics.

Clindamycin (Cleocin, Cleocin Pediatric, ClindaMax Vaginal)

Clindamycin is a lincosamide for the treatment of serious skin and soft-tissue staphylococcal infections. It is effective against aerobic and anaerobic streptococci (except enterococci). It inhibits bacterial growth, possibly by blocking the dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Meropenem (Merrem)

Meropenem is a bactericidal broad-spectrum carbapenem antibiotic that inhibits cell-wall synthesis. It is effective against most gram-positive and gram-negative bacteria. It has slightly increased activity against gram-negatives and slightly decreased activity against staphylococci and streptococci compared with imipenem.

Tigecycline (Tygacil)

Tigecycline is a glycylcycline antibiotic that is structurally similar to tetracycline antibiotics. It inhibits bacterial protein translation by binding to the 30S ribosomal subunit, and it blocks entry of amino-acyl tRNA molecules in the ribosome A site.


Tetracycline inhibits bacterial protein synthesis by binding with the 30S and, possibly, 50S ribosomal subunit(s). Tetracycline has anti-inflammatory activity. Administer at 250-500 mg PO bid.

Doxycycline (Doryx, Adoxa, Monodox, Vibramycin)

Doxycycline is a broad-spectrum antibiotic with excellent gram-positive coverage, including most resistant staphylococcal organisms. It inhibits protein synthesis and, thus, bacterial growth, by binding to the 30S and possibly 50S ribosomal subunits of susceptible bacteria. It may block the dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.



Class Summary

Topical corticosteroid lotions have proven helpful in controlling the generalized pruritus and the evolution of the lesions in patients with perforating folliculitis.

Hydrocortisone topical (Cortizone-10,Hydroskin)

Hydrocortisone topical is a moderate-potency adrenocorticosteroid derivative suitable for application to skin or external mucous membranes. It has mineralocorticoid and glucocorticoid effects, resulting in anti-inflammatory activity.

Fluticasone (Cutivate)

Fluticasone is a high-potency topical corticosteroid that inhibits cell proliferation. It is immunosuppressive and anti-inflammatory.