Laugier-Hunziker Syndrome Differential Diagnoses

Updated: Jun 27, 2019
  • Author: Christen M Mowad, MD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

The most common cause of mucosal pigmentation is physiological and is often diffuse and bilateral. Other causes of oral pigmentation include smoker’s melanosis, postinflammatory melanosis, pharmacologically induced pigmentation in association with medications, Peutz-Jeghers syndrome, and Addison disease. Also consider the following:

  • Amalgam tattoo
  • Contact mucositis
  • Chemicals and/or minerals (eg, arsenic, fluoride)
  • Drug-induced hyperpigmentation
  • Friction-induced longitudinal melanonychia of the toenails
  • Heavy metal exposure
  • Infection
  • Malnutrition (eg, vitamin B-12 deficiency) [21]
  • Melanoma [6]
  • Peutz-Jeghers syndrome
  • Physiologic melanoplakia and melanonychia
  • Smoking (ie, Smoker's Melanosis) [7]

Differential Diagnoses