Medical Care

Multinucleate cell angiohistiocytoma has not been shown to respond to any medical therapy.

Surgical Care

Surgical excision of multinucleate cell angiohistiocytoma may be recommended for cosmetic reasons.

Laser therapy has resulted in clinical resolution of the lesions with not scarring. Kopera et al reported successful treatment with an argon laser.^[18] Richer and Lui reported successful treatment with a 585-nm pulsed dye laser.^[19]

Treatment using intense pulsed light has also been reported.^[20]

Perez et al reported a case with a good response to cryosurgery.^[21]

Long-Term Monitoring

Further follow-up care is not needed because multinucleate cell angiohistiocytoma is not known to be associated with any systemic diseases and because it has a biologically benign course.

Medication

Smith NP, Wilson Jones E. Multinucleate cell angiohistiocytoma: a new entity. Br J Dermatol. 1985. 113(suppl 29):15.
Cesinaro AM, Roncati L, Maiorana A. Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into the pathogenesis of a reactive process. Am J Dermatopathol. 2010 Oct. 32(7):655-9. [QxMD MEDLINE Link].
Puig L, Fernandez-Figueras MT, Bielsa I, Lloveras B, Alomar A. Multinucleate cell angiohistiocytoma: a fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia. J Cutan Pathol. 2002 Apr. 29(4):232-7. [QxMD MEDLINE Link].
Shapiro PE, Nova MP, Rosmarin LA, Halperin AJ. Multinucleate cell angiohistiocytoma: a distinct entity diagnosable by clinical and histologic features. J Am Acad Dermatol. 1994 Mar. 30(3):417-22. [QxMD MEDLINE Link].
Roy SF, Dong D, Myung P, McNiff JM. Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. J Cutan Pathol. 2019 Aug. 46 (8):563-569. [QxMD MEDLINE Link].
Aloi F, Solaroli C, Tomasini C, Pippione M. Multinucleate cell angiohistiocytoma: a report of two cases. J Eur Acad Dermatol Venereol. 1998 Jul. 11(1):51-4. [QxMD MEDLINE Link].
Blanco Barrios S, Rodriguez Diaz E, Alvarez Cuesta C, Galache Osuna C, Requena Caballero C, Martinez Merino A, et al. Multinucleate cell angiohistiocytoma: a new case report. J Eur Acad Dermatol Venereol. 2005 Mar. 19(2):208-11. [QxMD MEDLINE Link].
Cribier B, Gambini C, Rainero M, Grosshans E. Multinucleate cell angiohistiocytoma. A review and report of four cases. Acta Derm Venereol. 1995 Sep. 75(5):337-9. [QxMD MEDLINE Link].
Jaconelli L, Kanitakis J, Ktiouet S, Faure M, Claudy A. Multinucleate cell angiohistiocytoma: report of three new cases and literature review. Dermatol Online J. 2009 Feb 15. 15(2):4. [QxMD MEDLINE Link].
Väkevä L, Saksela O, Kariniemi AL. Multinucleate cell angiohistiocytoma: a report of four cases in Finland. Acta Derm Venereol. 2003. 83(3):222-3. [QxMD MEDLINE Link].
Doane JA, Purdy K, Pasternak S. Generalized Multinucleate Cell Angiohistiocytoma. J Cutan Med Surg. 2015 May-Jun. 19 (3):323-5. [QxMD MEDLINE Link].
Moradi Tuchayi S, Garibyan L, Lee KC. Successful treatment of multinucleate cell angiohistiocytoma with fractionated ablative CO₂ laser. JAAD Case Rep. 2019 Apr. 5 (4):297-299. [QxMD MEDLINE Link]. [Full Text].
Frew JW. Multinucleate cell angiohistiocytoma: clinicopathological correlation of 142 cases with insights into etiology and pathogenesis. Am J Dermatopathol. 2015 Mar. 37 (3):222-8. [QxMD MEDLINE Link].
Jones AC, Mullins D, Jimenez F. Multinucleate cell angiohistiocytoma of the upper lip. Oral Surg Oral Med Oral Pathol. 1994 Dec. 78(6):743-7. [QxMD MEDLINE Link].
Rawal YB, Anderson KM, Rawal SY. Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour. Clin Exp Dermatol. 2009 Apr. 34(3):333-6. [QxMD MEDLINE Link].
Shields JA, Eagle RC Jr, Shields CL, Sohmer KK. Multinucleate cell angiohistiocytoma of the orbit. Am J Ophthalmol. 1995 Sep. 120(3):402-3. [QxMD MEDLINE Link].
Jones WE, Cerio R, Smith NP. Multinucleate cell angiohistiocytoma: an acquired vascular anomaly to be distinguished from Kaposi's sarcoma. Br J Dermatol. 1990 May. 122(5):651-63. [QxMD MEDLINE Link].
Kopera D, Smolle J, Kerl H. Multinucleate cell angiohistiocytoma: treatment with argon laser. Br J Dermatol. 1995 Aug. 133(2):308-10. [QxMD MEDLINE Link].
Richer V, Lui H. Facial multinucleate cell angiohistiocytoma: long-term remission with 585 nm pulsed dye laser. Clin Exp Dermatol. 2016 Apr. 41 (3):312-3. [QxMD MEDLINE Link].
Fernandez-Jorge B, del Pozo J, Garcia-Silva J, Barja JM, Yebra-Pimentel MT, Fonseca E. Multinucleate cell angiohistiocytoma: treatment using intense pulsed light. Dermatol Surg. 2009 Jul. 35(7):1141-3. [QxMD MEDLINE Link].
Perez LP, Zulaica A, Rodriguez L, et al. Multinucleate cell angiohistiocytoma. Report of five cases. J Cutan Pathol. 2006 May. 33(5):349-52. [QxMD MEDLINE Link].

Media Gallery

Biopsy specimen of multinucleate cell angiohistiocytoma. A vascular proliferation is embedded in a stroma rich in fibroblasts and histiocytes, some of which are multinucleated.
Bizarre multinucleated cells are present in the stroma surrounding the vascular proliferation.

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Author

Diane M Scott, MD Dermatologist, Arch Health Partners

Diane M Scott, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

Daniel Davis, MD Associate Professor, Departments of Dermatology, Otolaryngology, and Pathology, University of Arkansas for Medical Science

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Military Dermatologists, Phi Beta Kappa, Texas Dermatological Society

Disclosure: Nothing to disclose.

Paul Krusinski, MD Director of Dermatology, Fletcher Allen Health Care; Professor, Department of Internal Medicine, University of Vermont College of Medicine

Paul Krusinski, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Additional Contributors

Abdul-Ghani Kibbi, MD, FACP Professor and Chair, Department of Dermatology, American University of Beirut Medical Center, Lebanon

Disclosure: Nothing to disclose.

Acknowledgements

Frances Ramos-Ceballos Staff Physician, Department of Dermatology, University of Arkansas for Medical Sciences

Frances Ramos-Ceballos is a member of the following medical societies: American Academy of Dermatology, Phi Beta Kappa, and Women's Dermatologic Society

Disclosure: Nothing to disclose.