Multinucleate Cell Angiohistiocytoma Clinical Presentation

Updated: Nov 07, 2019
  • Author: Diane M Scott, MD; Chief Editor: William D James, MD  more...
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Multinucleate cell angiohistiocytoma presents as insidiously developing asymptomatic papules that usually develop on acral surfaces and tend to persist indefinitely.


Physical Examination

Multiple, grouped, well-circumscribed papules are red to violaceous to brownish in color. [13]

Multinucleate cell angiohistiocytoma lesions are smooth and firm, and they may be either dome shaped or flat topped.

A few cases of multinucleate cell angiohistiocytoma have been in an annular distribution, mimicking granuloma annulare.

Lesions of multinucleate cell angiohistiocytoma occur most commonly on the extremities. Acral areas such as the dorsal aspects of the hands, fingers, wrists, and legs are the most frequent sites. Unusual locations of multinucleate cell angiohistiocytoma include the forehead, the upper lip, the chest, oral cavity, and the orbit. [14, 15, 16]

Lesions usually are unilateral, but a few bilateral cases and one generalized case have been reported.

Multinucleate cell angiohistiocytoma lesions are usually asymptomatic to pruritic.