Syringoma Treatment & Management

Updated: Mar 27, 2019
  • Author: Christopher R Shea, MD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Oral isotretinoin and acitretin and topical tretinoin have been used to treat syringomas, and the application of topical atropine has been used to relieve pruritus. [25]

Application of topical adelmidrol, a semisynthetic cannabinoid, was beneficial in one case of giant vulvar syringoma; it may act via down-regulation of mast cell activation. [26]


Surgical Care

The main reason for treatment is cosmetic; in particular, patients commonly seek treatment for syringomas of the eyelids and cheeks, which may be conspicuous. The goal of therapy for syringomas should be the destruction of the tumor with minimal scarring and no recurrence. However, because syringomas are embedded within the dermis, complete removal is often unsuccessful and recurrence is common. [25]

No comparative studies and no long-term follow-up studies are available on which to base definitive recommendations for syringoma treatment. Possible treatments include the following:

  • Surgical excision with primary suturing

  • Scissor excision with secondary intention healing

  • Electrocautery [27]

  • Electrodesiccation and curettage

  • Carbon dioxide laser using the pinhole method of application or Er:YAG laser ablation [28, 29, 30]

  • Fractionated carbon dioxide laser ablation [31]

  • Cryotherapy

  • Dermabrasion

  • Trichloroacetic acid