Leiomyoma Medication

Updated: Jun 15, 2021
  • Author: Fnu Nutan, MD, FACP; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

In the management of multiple leiomyomas, drugs are used mainly for the control of associated pain. Calcium channel blockers and phenoxybenzamine are both reported to be effective.

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Alpha-adrenergic blocking agents

Class Summary

Phenoxybenzamine may alleviate pain, including cold-induced pain.

Phenoxybenzamine (Dibenzyline)

Phenoxybenzamine decreases smooth muscle contractions through long-lasting noncompetitive alpha-adrenergic blockade of postganglionic synapses at smooth muscles.

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Calcium channel blockers

Class Summary

These drugs inhibit the movement of calcium ions across the cell membrane and into smooth muscle cells. They also depress both impulse formation and conduction velocity.

Nifedipine (Adalat, Procardia)

Nifedipine may relax smooth muscles. Its effects in reducing pain are not understood.

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Anticonvulsants

Class Summary

Gabapentin is indicated for the treatment of partial seizures in adults and for the management of postherpetic neuralgia. It has also been used for a range of neuropathic pain conditions. The exact mechanism of action is unknown; however, it appears to interact with a high-affinity binding site in brain membranes (an auxiliary subunit of voltage-sensitive Ca2+ channels.

Gabapentin (Neurontin)

Gabapentin is a membrane stabilizer, a structural analogue of the inhibitory neurotransmitter GABA, which paradoxically is thought not to exert effects on GABA receptors. It appears to exert action via the alpha(2)delta1 and alpha(2)delta2 auxiliary subunits of voltage-gaited calcium channels. Gabapentin is used to manage pain and provide sedation in neuropathic pain.

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