Medication Summary
Topical corticosteroids with or without occlusion have not shown any benefit in infantile digital fibromatosis; however, intralesional corticosteroids or fluorouracil may prove beneficial. [14, 15]
Corticosteroids
Class Summary
Anti-inflammatory agents may induce regression of dermal infiltrative lesions.
Triamcinolone (Aristocort)
Triamcinolone is used for inflammatory dermatosis responsive to steroids. It decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Triamcinolone can be injected intralesionally.
Antimetabolites
Class Summary
These agents inhibit cell growth and proliferation.
Fluorouracil (Efudex, Adrucil, Fluoroplex)
Fluorouracil is a pyrimidine analogue that has been shown to inhibit dermal fibroblast proliferation and collagen synthesis in cell culture.
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Dermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification.
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Firm, nontender, erythematous nodule on the fifth finger of a 17-month-old boy.
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A dermal nodule extending into the subcutaneous fat.