Acrokeratosis Verruciformis of Hopf Treatment & Management

Updated: May 11, 2018
  • Author: Sarah Sweeney Pinney, MD, FAAD; Chief Editor: William D James, MD  more...
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Medical Care

The only effective treatment is superficial ablation. Treatment is not generally recommended, but medical and surgical treatments have been tried. [29] Applications of retinoic acid have been helpful in some individuals. Oral vitamin A derivatives have also been reported to have some success. [19, 29] Destruction of the lesions with cryotherapy or laser, especially destructive lasers such as a carbon dioxide or Nd:YAG laser, may be used. Untreated lesions persist and become more noticeable after prolonged sun exposure because of darkening.



Transformation to squamous cell carcinoma of the skin has been reported in two cases. [18]