Acrokeratosis Verruciformis of Hopf Medication

Updated: May 11, 2018
  • Author: Sarah Sweeney Pinney, MD, FAAD; Chief Editor: William D James, MD  more...
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Medication Summary

Tretinoin has been reported to have some effects in some individuals with these lesions. Additionally, in a reported case of acrokeratosis verruciformis of Hopf associated with keratoacanthomas, treatment with acitretin dramatically improved both conditions. [19]


Retinoid-like Agents

Class Summary

Decreased cohesiveness of abnormal hyperproliferative keratinocytes may reduce potential for malignant degeneration. Retinoids modulate keratinocyte differentiation and have been shown to reduce risk of skin cancer formation.

Tretinoin topical (Avita, Retin-A, Refissa, Tretin-X)

Topical tretinoin was developed to treat acne vulgaris. It alters maturation and differentiation of keratinocytes and reduces the thickness of the hyperkeratotic stratum corneum. Tretinoin has been used for a variety of conditions, including flat warts, abnormalities of keratinization, and other keratoses. It is available in 0.025%, 0.05%, and 0.1% concentrations in a variety of vehicles, including gels, solutions, and creams.