Dermatologic Manifestations of Staphylococcal Scalded Skin Syndrome Medication

Updated: Apr 25, 2017
  • Author: Elizabeth U Rogozinski, MD, MS; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goal of pharmacotherapy for staphylococcal scalded skin syndrome (SSSS) is to reduce morbidity and to prevent complications. [44, 45]

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Antibiotics

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting. The empiric antibiotic regime should include a penicillinase-resistant penicillin and clindamycin. First- or second-generation cephalosporins can be used in place of penicillins.

Dicloxacillin (Dycill, Dynapen)

Dicloxacillin is for the treatment of infections caused by penicillinase-producing staphylococci. It should be used as empiric therapy in combination with clindamycin when staphylococcal infection is suspected and susceptibilities are pending.

Clindamycin (Cleocin, Cleocin Pediatric, ClindaMax Vaginal)

Clindamycin is a bacteriostatic protein synthesis inhibitor that has efficacy in treating MRSA. It should be used as empiric therapy in combination with a penicillinase-resistant penicillin when staphylococcal infection is suspected and susceptibilities are pending.

Mupirocin (Bactroban)

Mupirocin inhibits bacterial growth by inhibiting RNA and protein synthesis and should be used only at the site of S aureus infection. 

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