Antenatal Hydronephrosis (Urinary Tract Dilation) Medication

Updated: Jul 27, 2021
  • Author: Dennis B Liu, MD; Chief Editor: Marc Cendron, MD  more...
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Medication

Glucocorticoids

Class Summary

These agents elicit anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

Betamethasone (Celestone Soluspan)

Prenatal betamethasone is administered to pregnant women according to the recommendations by a National Institutes of Health (NIH) Consensus Conference Panel for all pregnancies at 24-34 weeks' gestation at risk of preterm delivery, preterm premature rupture of membranes (PROM) at 30-32 weeks' gestation, and in complicated pregnancies with anticipated delivery at < 34 weeks' gestation. Reduces neonatal mortality rates, respiratory distress syndrome (RDS), and intraventricular hemorrhage (IVH).

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Surfactants

Class Summary

Exogenous surfactant can be helpful in treatment of airspace disease (eg, RDS). Following inhaled administration, surface tension is reduced and alveoli are stabilized, thus decreasing the work of breathing and increasing lung compliance.

Beractant (Survanta)

A semisynthetic bovine lung extract containing phospholipids, fatty acids, and surfactant-associated proteins B (7 mcg/mL) and C (203 mcg/mL).

Calfactant (Infasurf)

A natural calf lung extract containing phospholipids, fatty acids, and surfactant-associated proteins B (260 mcg/mL) and C (390 mcg/mL).

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