Pediatric Selective Serotonin Reuptake Inhibitor Toxicity Questions & Answers

Updated: Sep 27, 2019
  • Author: Mohamed K Badawy, MD, FAAP; Chief Editor: Stephen L Thornton, MD  more...
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Questions & Answers

Overview

What are selective serotonin reuptake inhibitors (SSRIs)?

Which selective serotonin reuptake inhibitor (SSRI) has the highest toxicity?

What is the US Food and Drug Administration (FDA) black box warning for pediatric use of selective serotonin reuptake inhibitors (SSRIs)?

What is serotonin syndrome?

What is the pathophysiology of selective serotonin reuptake inhibitor (SSRI)?

What causes serotonin syndrome?

What is the prevalence of selective serotonin reuptake inhibitor (SSRI) toxicity?

What is the prognosis for selective serotonin reuptake inhibitor (SSRI) toxicity?

What is included in patient education about selective serotonin reuptake inhibitor (SSRI) toxicity?

Presentation

Which clinical history findings are characteristic of acute selective serotonin reuptake inhibitor (SSRI) toxicity?

Which clinical history findings are characteristic of serotonin syndrome?

Which physical exam findings are characteristic of selective serotonin reuptake inhibitor (SSRI) toxicity?

DDX

How is serotonin syndrome differentiated from neuroleptic malignant syndrome (NMS)?

What are the differential diagnoses for Pediatric Selective Serotonin Reuptake Inhibitor Toxicity?

Workup

Which lab tests are performed in the workup for selective serotonin reuptake inhibitor (SSRI) toxicity?

When is chest radiography indicated in the workup for selective serotonin reuptake inhibitor (SSRI) toxicity?

What is the role of electrocardiography in the workup for selective serotonin reuptake inhibitor (SSRI) toxicity?

Treatment

How is selective serotonin reuptake inhibitor (SSRI) toxicity treated?

Which specialist consultations are beneficial to a patient with selective serotonin reuptake inhibitor (SSRI) toxicity?

How should patients with selective serotonin reuptake inhibitor (SSRI) toxicity be monitored?

How is selective serotonin reuptake inhibitor (SSRI) toxicity prevented?

What is included in emergency department (ED) care for selective serotonin reuptake inhibitor (SSRI) toxicity?

How is hyperthermia managed in patients with selective serotonin reuptake inhibitor (SSRI) toxicity?

Medications

What is the role of medications in the treatment of selective serotonin reuptake inhibitor (SSRI) toxicity?

Which medications in the drug class Sedatives and Anticonvulsants are used in the treatment of Pediatric Selective Serotonin Reuptake Inhibitor Toxicity?

Which medications in the drug class Antidotes, Other are used in the treatment of Pediatric Selective Serotonin Reuptake Inhibitor Toxicity?

Which medications in the drug class Antihypertensives, Other are used in the treatment of Pediatric Selective Serotonin Reuptake Inhibitor Toxicity?

Which medications in the drug class Decontaminants are used in the treatment of Pediatric Selective Serotonin Reuptake Inhibitor Toxicity?